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KMID : 0606920110190040460
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Biomolecules & Therapeutics
2011 Volume.19 No. 4 p.460 ~ p.465
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The Inhibitory Effect of Quercetin on the Agonist-Induced Regulation of Vascular Contractility
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Je Hyun-Dong
Jeong Ji-Hoon
La Hyen-O
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Abstract
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The present study was undertaken to investigate the infl uence of quercetin on vascular smooth muscle contractility and to de-termine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Quercetin at a low concentration (0.01-0.03 mM) directly and more signifi cantly relaxed fl uoride or thromboxane A2-induced vascular contraction than phorbol ester-induced contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, quercetin more signifi cantly inhibited thromboxane A2-induced increases in pMYPT1 levels than phorbol ester-induced increases. It also more signifi cantly inhibited thromboxane A2-induced increases in pMYPT1 levels than pERK1/2 levels suggesting the mechanism involving the primarily inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1. This study provides evi-dence regarding the mechanism underlying the relaxation effect of quercetin on agonist-induced vascular contraction regardless of endothelial function.
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KEYWORD
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ERK1/2, Fluoride, MYPT1, Phorbol ester, Quercetin, Rho-kinase, Vasodilation
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